Accessories
12
WindTunnel Autosampler Enclosure
Austosampler Enclosure Austosampler Enclosure XLR8
WindTunnel Autosampler Enclosure
WindTunnel Autosampler Enclosure 70-803-1148
WindTunnel Autosampler Enclosure XLR8 70-803-1199
WindTunnel Fan Aus 70-803-1149
WindTunnel Fan Eur 70-803-1150
WindTunnel Fan USA 70-803-1151
WindTunnel Filter 70-803-1152
WindTunnel Flange 70-803-1153
WindTunnel Base 70-803-1178
WindTunnel Base for XLR8 Enclosure 70-803-1205
High Sensitivity Single-Cell Sample
Introduction System for ICP-MS
Single-cell analysis using an Inductively Coupled Plasma-Mass Spectrometer
(SC-ICP-MS) is enhancing the fundamental understanding in cellular biology,
oncology and drug discovery. SC-ICP-MS provides for the quantification of
metals in individual biological cells and is used as a research tool to allow
scientists to study disease aetiology, better understand diseased cell states
and develop new drug treatments to give better patient outcomes.
In single-cell analysis, the sample introduction system converts a continuous
stream of biological cells efficiently into an aerosol of individual cells and
transfers the aerosol into the Inductively Coupled Plasma of the ICP-MS
for analysis. A critical aspect of the sample introduction system is the cells
must remain intact and unruptured during the nebulization process to ensure
each individual cell produces a single ion burst inside the plasma that can be
transferred into the mass analyser of the ICP-MS for quantification.
Conventional ICP-MS spray chambers have low transport efficiencies
(typically < 5% TE) that filter out larger droplets ( > 5um) from the nebulizer
aerosol. As most cell lines of interest are larger than 5um, the secondary
filtering mechanism of conventional spray chamber designs rejects a
high proportion of the cells from passing to the plasma. To overcome this
significant deficiency the Glass Expansion spray chamber design for single
cell analysis is different from conventional ICP-MS spray chambers.
Glass Expansion have developed a high sensitivity Single-Cell Sample
Introduction system which consists of:
• High efficiency, low uptake, concentric glass nebulizer designed to
efficiently nebulize single-cell suspensions without compromising cell
integrity
• Low volume, on-axis, laminar-flow spray chamber directly coupled to the
ICP for the highest transport efficiency of the nebulized single-cell
• Patent pending MicroJet gas adapter which entrains and shapes the
aerosol plume to reduce cell deposition onto the spray chamber walls and
increase sample transport efficiency suspension
Single-Cell Sample Introduction System
For Agilent 7900 ICP-MS KT-1155
The WindTunnel autosampler enclosure will protect your samples
against airborne contaminants and also protect analysts from fumes and
odours. Its versatile configuration makes it suitable for the most common
laboratory situations:
Filtered positive pressure enclosure. When fitted with the optional fan
and HEPA filter, the WindTunnel provides a positive pressure enclosure.
Vented enclosure. The addition of the optional flange, allows the fumes to
be removed through a laboratory exhaust system (not supplied).
Dust cover. The WindTunnel can be used without the fan and filter to
function as a convenient dust cover.
• Suitable for the Cetac 130, 260, 280, 520, 520HS and 560 plus PerkinElmer
AS93+ and S10, and Agilent SPS-3 autosamplers
• Shatter-proof polycarbonate construction
• Easy access through front and rear roll-up doors
• Optional fan maintains positive pressure
• Optional HEPA filter
• Optional exhaust port flange
• Multiple ports for tubing and power cords
• Larger model suitable for Cetac XLR8 and XLR-860 autosampler
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