The IsoMist Programmable Temperature Spray Chamber

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Application Notes

Enhanced Performance for ICP-MS and ICP-OES

The IsoMist Programmable Temperature Spray Chamber, provides the benefits of a temperature-controlled ICP sample introduction system in a compact, convenient package.

Figure 1. IsoMist

Peltier Effect Temperature Control

The temperature is electronically controlled using a powerful inbuilt Peltier device. You can select any temperature between -10°C and +60°C in 1°C increments to provide the optimum conditions for any application. The rapid response of the Peltier device allows a spray chamber temperature of -5°C to be reached within 15 minutes.

Versatile Computer Interface

For maximum convenience, the IsoMist can be controlled from your PC via a Bluetooth® wireless interface or a standard USB network connection. The spray chamber temperature can be monitored through a temperature versus time plot on your PC screen. And, for regulatory compliance, the temperature versus time data file can be saved with your results. If these features are not required, once the temperature has been programmed, the IsoMist can be run in stand-alone mode without a PC connection.

Reduced Oxide Interferences in ICP-MS

By introducing the sample at low temperature, the IsoMist reduces oxides as shown in Figure 2, resulting in fewer interferences and improved detection limits.

Figure 2. Effect of IsoMist Temperature on ICP-MS Oxide Ratio; Data Courtesy of David Jones, ALS Chemex.

Perfect for Volatile Organics

The temperature can be set as low as -10°C to reduce the solvent load on the plasma and allow the straightforward ICP-MS or ICP-OES analysis of even the most volatile organic solvents, as shown in Figure 3.

Figure 3. Reproducibility of naphtha results at -10°C (measurements at 90 minute interval)

Constant Temperature Improves Stability

By holding the spray chamber at a constant temperature, the IsoMist significantly improves long-term signal stability, increasing the likelihood of calibration checks passing. Figure 4 shows the emission signals over 3 hours with the temperature held at a constant 21°C compared with a standard system at ambient temperature.

Figure 4. Effect of constant temperature on signal stability.

Heating Mode Enhances Sensitivity

The sensitivity for many analyses is enhanced by running the spray chamber at an elevated temperature, a feature that is particulary important for samples with limited volume. The following table shows that the detection limit with a sample uptake of 20µL/min is better at 60C than 21°C and is almost as good as that obtained with a standard system running at 21°C with a sample uptake of 2mL/min.

Figure 5. Detection limits at 21°C and 60°C

Proven Cyclonic Spray Chamber

The IsoMist incorporates the proven Twister cyclonic spray chamber, combining excellent sensitivity and precision with exceptionally fast washout. The Helix nebulizer interface has zero dead volume and provides for convenient nebulizer insertion and removal. This system is compatible with the full range of Glass Expansion nebulizers.

Figure 6. Encapsulated Twister Spray Chamber

Completely Self-Contained Ergonomic Package

The compact design includes a rugged, low maintenance, chemically-resistant polypropylene housing. It provides a much more convenient alternative to a jacketed spray chamber with an external chiller because it does not require an external source of coolant. It is compatible with almost all ICP-MS and ICP-OES models.


Optional PFA and Quartz Spray Chambers

The IsoMist can be used with PFA or quartz spray chambers in addition to the standard glass Twister spray chamber. Please contact for information on suitable PFA or quartz spray chamber for your IsoMist.

The IsoMist can also be ordered with a PFA or quartz spray chamber installed in place of the standard glass spray chamber. Simple add a "P" for PFA or a "Q" for quartz to the part number for the standard kit, eg. KT-1010P for PFA or KT-1010Q for quartz.

Twinnabar Spray Chamber

The IsoMist can be configured with a low volume (20mL) Twinnabar spray chamber for applications with limited sample volume. Note that a special IsoMist version is required - the Twinnabar cannot be used in the standard IsoMist. Please contact for full details.

Ordering Information

We have established an IsoMist Kit for common ICP-OES and ICP-MS models. Each kit contains the IsoMist module, encapsulated Twister spray chamber, torch interface and mounting bracket (if required). Please select the kit to match your ICP from the following:

IsoMist Programmable Temperature Spray Chambers

Part Number Description
KT-1010 IsoMist Kit for Agilent ® 7500
KT-1103 IsoMist Kit for Agilent ® 7700/8800/8900
KT-1140 IsoMist Kit for Agilent ® 7800/7900
KT-1053 IsoMist Kit for Agilent ® 4500
KT-1137 IsoMist Kit for Agilent ® 5100/5110/5800/5900
KT-1014 IsoMist Kit for Agilent ® (Varian) 700-ES or Vista Axial
KT-1022 IsoMist Kit for Agilent ® (Varian) 700-ES or Vista Radial
KT-1054 IsoMist Kit for Agilent ® (Varian) 700-ES or Vista Axial All Glass System
KT-1055 IsoMist Kit for Agilent ® (Varian) 700-ES or Vista Radial All Glass System
KT-1119 IsoMist Kit for Agilent ® 4100/4200 MP-AES
KT-1017 IsoMist Kit for Bruker (Varian) 800-MS
KT-1042 IsoMist Kit for GBC OptiMass
KT-1064 IsoMist Kit for Horiba ® Jobin Yvon
KT-1011 IsoMist Kit for PerkinElmer ® Optima 4300/5300/7300V
KT-1012 IsoMist Kit for PerkinElmer ® Optima 2000/4000/5000/7000/8000DV
KT-1063 IsoMist Kit for PerkinElmer ® Optima 3000 Axial/DV
KT-1096 IsoMist Kit for PerkinElmer ® NexION 300
KT-1013 IsoMist Kit for PerkinElmer ® Elan
KT-1067 IsoMist Kit for Shimadzu ®
KT-1121 IsoMist Kit for Spectro™ Arcos
KT-1141 IsoMist Kit for Spectro™ Blue
KT-1015 IsoMist Kit for Thermo ® 6000/7000 Duo
KT-1021 IsoMist Kit for Thermo ® 6000/7000 Radial
KT-1018 IsoMist Kit for Thermo ® Iris Axial/Duo
KT-1058 IsoMist Kit for Thermo ® Iris Radial
KT-1020 IsoMist Kit for Thermo ® Finnigan Element
KT-1023 IsoMist Kit for Thermo ® (VG) PlasmaQuad
KT-1025 IsoMist Kit for Thermo ® X Series
KT-1024 IsoMist Basic Kit ROL
KT-1027 IsoMist Basic Kit LOL

Please email us at if your model is not listed.

Customer comments

In terms of doing multi element analysis on spirit samples the IsoMist has proved itself to be a very useful tool.

Beverage manufacturer - UK

(In reference to the IsoMist) We are getting around 40% increased sensitivity over what we had before. Also, the QC recoveries for the problem elements B, Al and Zn seem to be much improved.

Health laboratory - Australia

We have all instruments using the Niagara Plus and the IsoMist and have increased efficiencies by up to 40% and over-all quality has also shown improvements, so we are very happy with them.

Minerals laboratory - Australia

So far we are very happy with the IsoMist spray chamber. The detection limits are better and the intensities are more stable from run to run.

Precious metals laboratory - Australia

The IsoMist has significantly boosted our productivity. It is so stable that I need only run a CCV and CCB at the beginning of the day and then start running samples. No need to restandardize daily.

Environmental laboratory - USA.

I've been operating the IsoMist on the 6500 at 27 degrees centigrade ... the improvement in stability has been dramatic ... I am thrilled at the linearity with little shift throughout a complex standardization and sample run.

Precious metals laboratory - USA

The equipment works extraordinarily well. Keeping temperature at 5degC the noise drops to half as much as without the IsoMist. There is no problem at all with temperature stability and the signal is twice as much as the one obtained without the IsoMist.

University laboratory - Spain

I would enthusiastically recommend the IsoMist to anyone trying to minimize oxide formation in ICP-MS.

Government laboratory - USA

The IsoMist was a treat because it took the place of the jacketed spray chamber, the heated bath, delivery tubes, and pump. It also eliminated my worries about leaks in my sample chamber. It is a small, neat package.

Oil company - USA

We are very happy with the performance of the IsoMist.

University - Belgium